OEM Factory for Tongkat Ali Root Powder - Bitter Almond Extract – Uniwell

Basic Information:

Product Name: Bitter Almond Extract                                      Molecular formula: C₂₀H₂₇NO₁₁

Extraction solvent: Ethanol and water                                   Molecular weight: 457.42

Country of Origin: China                                                          Irradiation: Non-irradiated

Identification: TLC                                                                    GMO: Non-GMO

Carrier/Excipients: None                                                         HS CODE: 1302199099

Amygdalin mainly exists in apricot, almond, peach, nectarine, loquat, plum, apple, black cherry and other nuts and leaves. Amygdalin does not exist in the skin of amygdalin。

Function:

1. the effect of amygdalin on cardiovascular

2. the effect of amygdalin on digestive system

1) Anti gastric ulcer: the effects of amygdalin on experimental gastric ulcer were observed by establishing the model of mice bound frozen stress gastric ulcer, acetic acid burning ulcer model and rats’ gastric ulcer model of ligation of pylorus. The results showed that the group of 20 and 40 mg/kg of amygdalin could inhibit the binding freezing stress gastric ulcer in mice; 5. The 10 and 20 mg / kg groups could promote the healing of the ulcer; 10. The ulcer area of gastric ulcer caused by pylorus ligation was reduced in 20 mg / kg group, suggesting that amygdalin had better anti ulcer effect.

2) Liver fibrosis: the model of bleomycin was established by tracheal exposure method. Amygdalin 15 mg/kg was injected intraperitoneally to investigate the effect of it on the expression of collagen I and III in bleomycin rats. On the 7th, 14th and 28th days of modeling, the area percentage of collagen type III in amygdalin group was lower than that of bleomycin group, and the percentage of type I collagen area in lung tissue of amygdalin group decreased on the 28th day. It was suggested that amygdalin could inhibit the formation of collagen I and III, and effectively slow down the process of pulmonary fibrosis in experimental rats, suggesting that the drug might be used in the prevention and treatment of human pulmonary fibrosis.

3. the effect of amygdalin on urinary system: the model of renal interstitial fibrosis was established by unilateral ureteral obstruction. The rats were given 3, 5 mg / D by gavage in amygdalin group, and the animals were killed 7,14,21 days after operation, and the pathological damage of kidney in each group was observed. The results showed that the renal fibrosis degree of the amygdalin group was significantly lower than that of the unilateral ureteral obstruction group at 21 days, of which the treatment group of 3 mg / D decreased 35%, and the treatment group of 5mg / D decreased by 28%. It was shown that amygdalin could obviously reduce the degree of renal pathological damage and delay the process of renal interstitial fibrosis, and further proved that amygdalin had anti fibrosis effect;

4. the effect of amygdalin on the immune system

5. ntitumor effect of amygdalin: 1.25 to 10g/L amygdalin in bladder cancer cells (UMUC-3, RT112, TCCSUP) 3 times a week, 2 weeks later found that amygdalin dose dependent inhibition of tumor cell growth and reproduction, so that it stagnate in the G0/ G1 phase, and 10 g /L when the best effect. The migration and attachment ability of umuc-3 and RT112 decreased significantly under the action of 10 g / L amygdalin, but the migration ability of tccsup increased, suggesting that amygdalin could regulate the integrin β 1 or β 4, it affects the attachment and migration of bladder cancer cells, and its effect is related to cell type.

6. the effect of amygdalin on respiratory system

Packing details:

Inner packing: Double PE bag

Outer packing: Drum ( Paper drum or Iron ring drum)

Delivery time: Within 7 days after get the payment

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